Radiation Damage in Protein Crystallography at X-ray Free-electron Lasers

نویسنده

  • Karol Jan Nass
چکیده

The ultrafast radiation damage begins with photoionization, followed by impact ionization by photoand Auger electrons. The ionization of atoms develops with time, ultimately causing lattice disorder and Coulomb explosion of the crystal. Due to very short pulse duration, it has been proposed that diffraction can be recorded before significant structural changes occur. This has been termed “diffraction-before-destruction”. However, achieving sufficient scattering signal for measuring nanocrystals or noncrystalline single particles requires higher power densities than those used in microcrystallography experiments.

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تاریخ انتشار 2017